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1.
Int J Mol Sci ; 23(2)2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-35054906

RESUMO

COVID-19 is a trending topic worldwide due to its immense impact on society. Recent trends have shifted from acute effects towards the long-term morbidity of COVID-19. In this review, we hypothesize that SARS-CoV-2 contributes to age-related perturbations in endothelial and adipose tissue, which are known to characterize the early aging process. This would explain the long-lasting symptoms of SARS-CoV-2 as the result of an accelerated aging process. Connective tissues such as adipose tissue and musculoskeletal tissue are the primary sites of aging. Therefore, current literature was analyzed focusing on the musculoskeletal symptoms in COVID-19 patients. Hypovitaminosis D, increased fragility, and calcium deficiency point towards bone aging, while joint and muscle pain are typical for joint and muscle aging, respectively. These characteristics could be classified as early osteoarthritis-like phenotype. Exploration of the impact of SARS-CoV-2 and osteoarthritis on endothelial and adipose tissue, as well as neuronal function, showed similar perturbations. At a molecular level, this could be attributed to the angiotensin-converting enzyme 2 expression, renin-angiotensin system dysfunction, and inflammation. Finally, the influence of the nicotinic cholinergic system is being evaluated as a new treatment strategy. This is combined with the current knowledge of musculoskeletal aging to pave the road towards the treatment of long-term COVID-19.


Assuntos
Envelhecimento , COVID-19/patologia , Osteoartrite/patologia , Tecido Adiposo/metabolismo , Tecido Adiposo/fisiopatologia , Enzima de Conversão de Angiotensina 2/metabolismo , COVID-19/complicações , COVID-19/virologia , Humanos , Sistema Musculoesquelético/metabolismo , Sistema Musculoesquelético/fisiopatologia , Osteoartrite/complicações , Dor/etiologia , Sistema Renina-Angiotensina , SARS-CoV-2/isolamento & purificação
2.
Rev. bras. ortop ; 57(1): 1-13, Jan.-Feb. 2022. tab
Artigo em Inglês | LILACS | ID: biblio-1365754

RESUMO

Abstract Skeletal muscle tissue has the largest mass in the human body, accounting for 45% of the total weight. Muscle injuries can be caused by bruising, stretching or laceration. The current classification divides these injuries into mild, moderate and severe. The signs and symptoms of grade I lesions are edema and discomfort; grade II, loss of function, gaps and possible ecchymosis; and grade III, complete rupture, severe pain and extensive hematoma. The diagnosis can be confirmed by ultrasound, which is dynamic and cheap, but examiner dependent; and magnetic resonance imaging (MRI), which provides better anatomical definition. The initial phase of the treatment consists in protection, rest, optimal use of the affected limb, and cryotherapy. Nonsteroidal anti-inflammatory drugs (NSAIDs), ultrasound therapy, strengthening and stretching after the initial phase and range of motion without pain are used in the clinical treatment. On the other hand, surgery has precise indications: hematoma drainage and muscle-tendon reinsertion and reinforcement.


Resumo O tecido muscular esquelético possui a maior massa do corpo humano, correspondendo a 45% do peso total. As lesões musculares podem ser causadas por contusões, estiramentos ou lacerações. A atual classificação separa as lesões entre leves, moderadas e graves. Os sinais e sintomas das lesões grau I são edema e desconforto; grau II, perda de função, gap e equimose eventual; grau III, rotura completa, dor intensa e hematoma extenso. O diagnóstico pode ser confirmado por ultrassom (dinâmico e barato, porém examinador-dependente); e ressonância magnética (RM) (maior definição anatômica). A fase inicial do tratamento se resume à proteção, ao repouso, ao uso otimizado do membro afetado e crioterapia. Anti-inflamatórios não hormonais (AINHs), ultrassom terapêutico, fortalecimento e alongamento após a fase inicial e amplitudes de movimento sem dor são utilizados no tratamento clínico. Já o cirúrgico possui indicações precisas: drenagem do hematoma, reinserção e reforço musculotendíneos.


Assuntos
Traumatismos em Atletas , Anti-Inflamatórios , Sistema Musculoesquelético/cirurgia , Sistema Musculoesquelético/fisiopatologia , Sistema Musculoesquelético/lesões
3.
PLoS One ; 16(11): e0259440, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34793483

RESUMO

This study aims to investigate the dysfunction and recovery of the lumbopelvic movement and motor control of people with chronic nonspecific low back pain after a structured rehabilitation which emphasizes on re-education and training of movement and motor control. The lumbopelvic movement and motor control pattern of 30 adults (15 with chronic low back pain, 15 healthy controls) were assessed using 3D motion and electromyographic analysis during the repeated forward bending test, in additional to the clinical outcome measures. Regional kinematics and muscle recruitment pattern of the symptomatic group was analysed before and after the 6-week rehabilitation, and compared to healthy controls. Significant improvement in back pain, functional capacity and self-efficacy of the symptomatic group was found after the rehabilitation. Patients with chronic nonspecific low back pain were capable to recover to a comparable level of the healthy controls in terms of their lumbopelvic movement and motor control pattern upon completion of a 6-week rehabilitation program, despite their dysfunction displayed at baseline. Phase specific motor control reorganization in which more profound and positive changes shown during the flexion phase. Our findings indicate that the recovery of the movement and motor control pattern in patients with chronic low back pain achieved to a comparable level of the healthy able-bodies. The improvement of both the physical outcome measures suggest that specific rehabilitation program which emphasizes on optimizing motor control during movements would help promoting the functional recovery of this specific low back pain subgroup.


Assuntos
Terapia por Exercício , Dor Lombar/reabilitação , Músculo Esquelético/fisiologia , Sistema Musculoesquelético/fisiopatologia , Fenômenos Biomecânicos , Estudos de Casos e Controles , Doença Crônica , Eletromiografia , Feminino , Humanos , Movimento , Avaliação de Programas e Projetos de Saúde , Estudos Prospectivos , Recuperação de Função Fisiológica , Autoeficácia , Resultado do Tratamento
5.
Sci Rep ; 11(1): 13788, 2021 07 02.
Artigo em Inglês | MEDLINE | ID: mdl-34215827

RESUMO

Motor imagery (MI) is usually facilitated when performed in a congruent body position to the imagined movement, as well as after actual execution (AE). A lower-limb amputation (LLA) results in important structural and functional changes in the sensorimotor system, which can alter MI. In this study, we investigated the effects of body position and AE on the temporal characteristics of MI in people with LLA. Ten participants with LLA (mean age = 59.6 ± 13.9 years, four females) and ten gender- and age-matched healthy control participants (mean age = 60.1 ± 15.4 years, four females) were included. They performed two locomotor-related tasks (a walking task and the Timed Up and Go task) while MI times were measured in different conditions (in congruent/incongruent positions and before/after AE). We showed that MI times were significantly shorter when participants imagined walking in a congruent-standing position compared to an incongruent-sitting position, and when performing MI after actual walking compared to before, in both groups. Shorter MI times in the congruent position and after AE suggest an improvement of MI's temporal accuracy (i.e. the ability to match AE time during MI) in healthy individuals but not in the LLA group.


Assuntos
Imagens, Psicoterapia , Sistema Musculoesquelético/fisiopatologia , Equilíbrio Postural/fisiologia , Caminhada/fisiologia , Adulto , Idoso , Amputação Cirúrgica/psicologia , Feminino , Humanos , Imaginação/fisiologia , Masculino , Pessoa de Meia-Idade , Movimento/fisiologia , Postura/fisiologia , Postura Sentada , Posição Ortostática , Estudos de Tempo e Movimento , Caminhada/psicologia
6.
PLoS One ; 16(6): e0252657, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34153069

RESUMO

Neuromuscular impairments are frequently observed in patients with chronic neck pain (CNP). This study uniquely investigates whether changes in neck muscle synergies detected during gait are sensitive enough to differentiate between people with and without CNP. Surface electromyography (EMG) was recorded from the sternocleidomastoid, splenius capitis, and upper trapezius muscles bilaterally from 20 asymptomatic individuals and 20 people with CNP as they performed rectilinear and curvilinear gait. Intermuscular coherence was computed to generate the functional inter-muscle connectivity network, the topology of which is quantified based on a set of graph measures. Besides the functional network, spectrotemporal analysis of each EMG was used to form the feature set. With the use of Neighbourhood Component Analysis (NCA), we identified the most significant features and muscles for the classification/differentiation task conducted using K-Nearest Neighbourhood (K-NN), Support Vector Machine (SVM), and Linear Discriminant Analysis (LDA) algorithms. The NCA algorithm selected features from muscle network topology as one of the most relevant feature sets, which further emphasize the presence of major differences in muscle network topology between people with and without CNP. Curvilinear gait achieved the best classification performance through NCA-SVM based on only 16 features (accuracy: 85.00%, specificity: 81.81%, and sensitivity: 88.88%). Intermuscular muscle networks can be considered as a new sensitive tool for the classification of people with CNP. These findings further our understanding of how fundamental muscle networks are altered in people with CNP.


Assuntos
Dor Crônica/fisiopatologia , Eletromiografia/métodos , Músculos do Pescoço/fisiopatologia , Cervicalgia/fisiopatologia , Máquina de Vetores de Suporte , Caminhada/fisiologia , Adulto , Algoritmos , Dor Crônica/classificação , Dor Crônica/diagnóstico , Feminino , Marcha/fisiologia , Humanos , Masculino , Modelos Teóricos , Sistema Musculoesquelético/fisiopatologia , Cervicalgia/classificação , Cervicalgia/diagnóstico , Músculos Paraespinais/fisiopatologia , Músculos Superficiais do Dorso/fisiopatologia , Adulto Jovem
7.
Physiol Res ; 70(2): 119-151, 2021 04 30.
Artigo em Inglês | MEDLINE | ID: mdl-33992043

RESUMO

The purpose of this systematic review is twofold: 1) to identify, evaluate, and synthesize the heretofore disparate scientific literatures regarding the effects of direct exposure to microgravity on the musculoskeletal system, taking into account for the first time both bone and muscle systems of both humans and animals; and 2) to investigate the efficacy and limitations of exercise countermeasures on the musculoskeletal system under microgravity in humans.The Framework for Scoping Studies (Arksey and O'Malley 2005) and the Cochrane Handbook for Systematic Reviews of Interventions (Higgins JPT 2011) were used to guide this review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist was utilized in obtaining the combined results (Moher, Liberati et al. 2009). Data sources, PubMed, Embase, Scopus, and Web of Science were searched for published articles through October 2019 using the Mesh terms of microgravity, musculoskeletal system, and exercise countermeasures. A total of 84 references were selected, including 40 animal studies and 44 studies with human participants. The heterogeneity in the study designs, methodologies, and outcomes deemed this review unsuitable for a meta-analysis. Thus, we present a narrative synthesis of the results for the key domains under five categories: 1) Skeletal muscle responses to microgravity in humans 2) Skeletal muscle responses to microgravity in animals 3) Adaptation of the skeletal system to microgravity in humans 4) Adaptation of the skeletal system to microgravity in animals 5) Effectiveness of exercise countermeasures on the human musculoskeletal system in microgravity. Existing studies have produced only limited data on the combined effects on bone and muscle of human spaceflight, despite the likelihood that the effects on these two systems are complicated due to the components of the musculoskeletal system being anatomically and functionally interconnected. Bone is directly affected by muscle atrophy as well as by changes in muscle strength, notably at muscle attachments. Given this interplay, the most effective exercise countermeasure is likely to be robust, individualized, resistive exercise, primarily targeting muscle mass and strength.


Assuntos
Terapia por Exercício , Doenças Musculoesqueléticas/prevenção & controle , Sistema Musculoesquelético/fisiopatologia , Voo Espacial , Contramedidas de Ausência de Peso , Ausência de Peso/efeitos adversos , Animais , Feminino , Humanos , Masculino , Doenças Musculoesqueléticas/diagnóstico , Doenças Musculoesqueléticas/etiologia , Doenças Musculoesqueléticas/fisiopatologia , Sistema Musculoesquelético/patologia , Fatores de Proteção , Medição de Risco , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento
8.
Pediatr Blood Cancer ; 68(8): e29053, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33890409

RESUMO

BACKGROUND: Children receiving intensive chemotherapy for leukemia or undergoing hematopoietic stem cell transplant (HSCT) for solid tumors or leukemia are at risk for musculoskeletal (MSK) impairment from their underlying disease and from treatment. Data are limited on the incidence and nature of these disorders during intensive therapy. This study's objective was to provide a cross-sectional description of MSK impairments in this population. PROCEDURE: Children with acute myeloid leukemia (AML), relapsed acute lymphoblastic leukemia (rALL), or undergoing HSCT were systematically assessed for MSK impairments as part of Children's Oncology Group study ACCL0934. Assessments occurred at study entry, at 2 months, and at 12 months and included evaluation for signs or symptoms of MSK impairment and the type, site, and diagnosis. RESULTS: Six hundred three patients were included. MSK signs or symptoms were present in 48 (8.0%) children at study entry, 64 (13.5%) children at 2 months, and 40 (11.6%) children at 12 months. Arthralgia and/or gait abnormalities were the most common impairments; the knee was the most common site. Arthritis and tendonitis were both rare. Vincristine neuropathy, MSK impacts from central nervous system pathology, and bone or joint pain from underlying cancer were the most common diagnoses. Multivariate analysis demonstrated that having rALL (odds ratio [OR] 2.00, 95% CI 1.07-3.76, p = .03) or obesity (OR 2.10, 95% CI 1.12-3.95, p = .02) were risk factors for MSK impairment at study entry. CONCLUSIONS: MSK impairments are common in this intensively treated patient population, especially in those with rALL and those who are obese.


Assuntos
Transplante de Células-Tronco Hematopoéticas , Leucemia Mieloide Aguda , Sistema Musculoesquelético/fisiopatologia , Leucemia-Linfoma Linfoblástico de Células Precursoras , Criança , Estudos Transversais , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Humanos , Leucemia Mieloide Aguda/tratamento farmacológico , Leucemia Mieloide Aguda/terapia , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia
9.
Pediatr Rheumatol Online J ; 19(1): 58, 2021 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-33926491

RESUMO

BACKGROUND: While musculoskeletal ultrasound (MSUS) use in pediatric rheumatology is becoming more common, the majority of pediatric MSUS literature continues to focus on ultrasound findings in healthy children and juvenile idiopathic arthritis with little discussion of other musculoskeletal problems that may mimic arthritis such as joint hypermobility. Chronic joint pain related to hypermobility is a common referral to pediatric rheumatology clinics. Our aim is to describe the musculoskeletal ultrasound (MSUS) characteristics of the knee in a population with joint hypermobility and pain in comparison to control participants. METHODS: Participants were recruited into three groups for a case-control study. Case group participants had knee hypermobility and pain symptoms (H + P). Participants in one control group had knee hypermobility without pain symptoms (H-P), and participants in the other control group had no knee hypermobility or pain symptoms (NP). B-mode and Doppler MSUS images were obtained and scored for each knee. Descriptive statistics are used for demographic variables and MSUS findings. Regression analysis is used to evaluate risk of synovial effusion and higher synovial effusion/hypertrophy quantitative score. RESULTS: MSUS assessment was performed on 91 knees of 50 participants. H + P knees were more likely to have positive findings noted on MSUS (94% vs. 70% of H-P and 74% of NP knees, p = 0.043). Patellar tendon hyperemia was more common in H + P knees (52%, vs. 19% among H-P and 23% among NP, p = 0.025). Participants who reported taking scheduled non-steroidal anti-inflammatory drugs (NSAIDs) had an increased risk of synovial effusion (RR = 1.83, 95% CI = 1.07-2.30, p = 0.026) and a trend towards increased risk of a higher synovial effusion/hypertrophy quantitative score (RR = 1.77, 95% CI = 0.92-3.38, p = 0.086). CONCLUSIONS: While positive MSUS findings were frequent in all participants, patellar tendon hyperemia was more frequent in participants with knee hypermobility and pain symptoms. Additionally, reported use of NSAIDs was associated with an increased risk of synovial effusion and higher synovial effusion/hypertrophy quantitative score. Further study should assess correlation between tendon abnormalities and degree of pain symptoms as well as the effect of NSAIDs on MSUS findings.


Assuntos
Artralgia/diagnóstico , Instabilidade Articular , Articulação do Joelho , Sistema Musculoesquelético , Ultrassonografia Doppler/métodos , Adolescente , Anti-Inflamatórios não Esteroides/uso terapêutico , Artralgia/etiologia , Estudos de Casos e Controles , Diagnóstico Diferencial , Feminino , Humanos , Hiperemia/diagnóstico por imagem , Instabilidade Articular/diagnóstico , Instabilidade Articular/fisiopatologia , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/fisiopatologia , Masculino , Sistema Musculoesquelético/diagnóstico por imagem , Sistema Musculoesquelético/fisiopatologia , Medição de Risco/métodos , Fatores de Risco , Tendões/irrigação sanguínea , Tendões/patologia
10.
Proc Nutr Soc ; 80(1): 73-91, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-32981540

RESUMO

The prevalence of malnutrition in patients with cancer is one of the highest of all patient groups. Weight loss (WL) is a frequent manifestation of malnutrition in cancer and several large-scale studies have reported that involuntary WL affects 50-80% of patients with cancer, with the degree of WL dependent on tumour site, type and stage of disease. The study of body composition in oncology using computed tomography has unearthed the importance of both low muscle mass (sarcopenia) and low muscle attenuation as important prognostic indications of unfavourable outcomes including poorer tolerance to chemotherapy; significant deterioration in performance status and quality of life (QoL), poorer post-operative outcomes and shortened survival. While often hidden by excess fat and high BMI, muscle abnormalities are highly prevalent in patients with cancer (ranging from 10 to 90%). Early screening to identify individuals with sarcopenia and decreased muscle quality would allow for earlier multimodal interventions to attenuate adverse body compositional changes. Multimodal therapies (combining nutritional counselling, exercise and anti-inflammatory drugs) are currently the focus of randomised trials to examine if this approach can provide a sufficient stimulus to prevent or slow the cascade of tissue wasting and if this then impacts on outcomes in a positive manner. This review will focus on the aetiology of musculoskeletal degradation in cancer; the impact of sarcopenia on chemotherapy tolerance, post-operative complications, QoL and survival; and outline current strategies for attenuation of muscle loss in clinical practice.


Assuntos
Desnutrição/terapia , Sistema Musculoesquelético/fisiopatologia , Neoplasias/fisiopatologia , Terapia Nutricional/métodos , Estado Nutricional/fisiologia , Composição Corporal , Caquexia/etiologia , Caquexia/terapia , Terapia Combinada , Humanos , Desnutrição/etiologia , Neoplasias/complicações , Avaliação Nutricional , Prevalência , Prognóstico , Qualidade de Vida , Sarcopenia/etiologia , Sarcopenia/terapia , Redução de Peso
11.
J Cell Physiol ; 236(6): 4231-4243, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33241566

RESUMO

MicroRNA-128 (miR-128) is associated with cell proliferation, differentiation, migration, apoptosis, and survival. Genetic analysis studies have demonstrated that miR-128 participates in bone metabolism, which involves bone marrow-derived mesenchymal stem cells, osteoblasts, osteoclasts, and adipocytes. miR-128 also participates in regeneration of skeletal muscles by targeting myoblast-associated proteins. The deregulation of miR-128 could lead to a series of musculoskeletal diseases. In this review, we discuss recent findings of miR-128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.


Assuntos
Remodelação Óssea , MicroRNAs/metabolismo , Desenvolvimento Muscular , Doenças Musculoesqueléticas/metabolismo , Sistema Musculoesquelético/metabolismo , Osteogênese , Artrite/genética , Artrite/metabolismo , Artrite/fisiopatologia , Remodelação Óssea/genética , Exossomos/genética , Exossomos/metabolismo , Regulação da Expressão Gênica , Humanos , Masculino , MicroRNAs/genética , Desenvolvimento Muscular/genética , Doenças Musculoesqueléticas/genética , Doenças Musculoesqueléticas/fisiopatologia , Sistema Musculoesquelético/fisiopatologia , Osteogênese/genética , Osteoporose/genética , Osteoporose/metabolismo , Osteoporose/fisiopatologia
12.
Ann N Y Acad Sci ; 1491(1): 3-24, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33231326

RESUMO

Aging is a chronic, complicated process that leads to degenerative physical and biological changes in living organisms. Aging is associated with permanent, gradual physiological cellular decay that affects all aspects of cellular mechanobiological features, including cellular cytoskeleton structures, mechanosensitive signaling pathways, and forces in the cell, as well as the cell's ability to sense and adapt to extracellular biomechanical signals in the tissue environment through mechanotransduction. These mechanobiological changes in cells are directly or indirectly responsible for dysfunctions and diseases in various organ systems, including the cardiovascular, musculoskeletal, skin, and immune systems. This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establishes mechanistic frameworks to understand the mechanobiological effects of aging on disease progression and to develop new strategies for halting and reversing the aging process. Our review also highlights the recent development of novel bioengineering approaches for studying the key mechanobiological mechanisms in aging.


Assuntos
Envelhecimento/fisiologia , Citoesqueleto/fisiologia , Mecanotransdução Celular/fisiologia , Sistema Musculoesquelético/fisiopatologia , Fenômenos Biomecânicos/fisiologia , Progressão da Doença , Elasticidade/fisiologia , Humanos , Debilidade Muscular/fisiopatologia
13.
Methods Mol Biol ; 2230: 17-37, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33197006

RESUMO

The study of postnatal skeletal repair is of immense clinical interest. Optimal repair of skeletal tissue is necessary in all varieties of elective and reparative orthopedic surgical treatments. However, the repair of fractures is unique in this context in that fractures are one of the most common traumas that humans experience and are the end-point manifestation of osteoporosis, the most common chronic disease of aging. In the first part of this introduction the basic biology of fracture healing is presented. The second part discusses the primary methodological approaches that are used to examine repair of skeletal hard tissue and specific considerations for choosing among and implementing these approaches.


Assuntos
Consolidação da Fratura , Fraturas Ósseas/terapia , Sistema Musculoesquelético/fisiopatologia , Osteoporose/terapia , Envelhecimento/patologia , Fraturas Ósseas/fisiopatologia , Humanos , Osteoporose/fisiopatologia
14.
PLoS One ; 15(10): e0240588, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33064756

RESUMO

INTRODUCTION: Diabetes-related lower extremity amputation has a major psycho-social and economic cost on the patient as well as a direct impact on financial expenditure within health facilities. AIM: This study aimed to determine the incidence and patient-related factors related to diabetes-related amputations amongst patients that were referred to the quaternary hospital between 1 January 2014 and 31 December 2015. METHODS: A retrospective cohort study. Data were retrieved from the medical record for each diabetes patient that was managed at IALCH during the study period. The following variables were collected: sociodemographic parameters (age, gender, and ethnicity) and diabetes-related parameters (type of diabetes) and additional complications. RESULTS: Ninety-nine patients (0, 73%) of all diabetes patients managed were new diabetes-related lower-extremity amputations. There were statistically significant increased odds of female patients (OR: 1, 7) and patients with non-insulin dependent diabetes (OR: 1, 64) to have new diabetes-related amputations. Patients older than 60 years (OR: 1, 31); African patients (OR: 1, 35) patients with cardiovascular complications (OR: 1, 04) and patients with retinopathy (OR: 1, 48) were more likely to have diabetes-related amputations but not statistically significant. CONCLUSIONS: A combination of primary preventive strategies, early detection and appropriate management of patients with diabetes and specific guidelines on the frequency, clinical and laboratory tests required for early diagnosis and referrals with early signs of diabetes-related complicationsat primary care level will assist in reducing the long term adverse outcomes including amputations.


Assuntos
Complicações do Diabetes/epidemiologia , Diabetes Mellitus Tipo 2/epidemiologia , Pé Diabético/cirurgia , Sistema Musculoesquelético/cirurgia , Adulto , Idoso , Amputação Cirúrgica , Complicações do Diabetes/fisiopatologia , Complicações do Diabetes/cirurgia , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/fisiopatologia , Diabetes Mellitus Tipo 2/cirurgia , Pé Diabético/patologia , Feminino , Hospitais , Humanos , Extremidade Inferior/fisiopatologia , Extremidade Inferior/cirurgia , Masculino , Pessoa de Meia-Idade , Sistema Musculoesquelético/fisiopatologia , Fatores de Risco , África do Sul
15.
J Occup Environ Med ; 62(9): 728-737, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32890212

RESUMO

OBJECTIVE: This research investigated the moderating role of supervisor support for employees with musculoskeletal complaints and their intentions to seek medical advice; take sick leave; transfer jobs; and resign. METHODS: Cross-sectional questionnaire data were collected from 1024 Australian employees. RESULTS: Regressions with bootstrapping revealed no support for the buffering role of supervisor support. In contrast to expectations, high supervisor support heightened, rather than lowered, musculoskeletal complaints on intentions to transfer jobs. For sick leave and resignation intentions, high supervisor support buffered the negative effects of musculoskeletal complaints for full-timers but exacerbated such intentions for part-timers. Furthermore, full-timers with high musculoskeletal complaints appeared more vulnerable to the exacerbating effects of low supervisor support compared with part-timers. CONCLUSIONS: Supervisor support for employees with musculoskeletal complaints both weakens and strengthens behavioral stress reactions, depending on employment status.


Assuntos
Emprego , Dor Musculoesquelética/epidemiologia , Sistema Musculoesquelético , Licença Médica , Austrália , Estudos Transversais , Humanos , Sistema Musculoesquelético/lesões , Sistema Musculoesquelético/fisiopatologia , Apoio Social , Inquéritos e Questionários , Local de Trabalho
16.
Chiropr Man Therap ; 28(1): 52, 2020 09 15.
Artigo em Inglês | MEDLINE | ID: mdl-32928244

RESUMO

BACKGROUND: Taping is a common treatment modality used by many rehabilitation providers. Several types of tapes and taping methods are used in the treatment of musculoskeletal dysfunction and pain. PURPOSE: To summarize and map the evidence related to taping methods used for various joints and conditions of the musculoskeletal system, and to provide clinicians and researchers with a user-friendly reference with organized evidence tables. DATA SOURCES: The PEDro, CINAHL, Cochrane Database of Systematic Reviews, Cochrane Central Register for Controlled Trials, PubMed, and PROSPERO databases were searched from inception through October 31, 2019. STUDY SELECTION: Eligible studies were selected by two independent reviewers and included either systematic reviews (SRs) or randomized controlled trials (RCTs) and included a musculoskeletal complaint using a clinical outcome measure. DATA EXTRACTION: Data was extracted by two investigators independently. Risk of bias and quality were assessed using A MeaSurement Tool to Assess systematic Reviews (AMSTAR) for SRs or the Physiotherapy Evidence Database (PEDro) scale for RCTs. The protocol was registered with PROSPERO (CRD42019122857). DATA SYNTHESIS: Twenty-five musculoskeletal conditions were summarized from forty-one SRs and 127 RCTs. There were 6 SRs and 49 RCTs for spinal conditions. Kinesio tape was the most common type of tape considered. Four evidence tables representing the synthesized SRs and RCTs were produced and organized by body region per condition. LIMITATIONS: Inclusion of only English language studies. Also, the heterogeneous nature of the included studies prevented a meta-analysis. CONCLUSIONS: There is mixed quality evidence of effectiveness for the different types of taping methods for different body regions and conditions. All of the SRs and RCTs found during our search of the taping literature have been organized into a series of appendices. A synthesis of the results have been placed in evidence tables that may serve as a useful guide to clinicians and researchers.


Assuntos
Fita Atlética , Doenças Musculoesqueléticas/terapia , Modalidades de Fisioterapia , Humanos , Doenças Musculoesqueléticas/fisiopatologia , Sistema Musculoesquelético/fisiopatologia , Modalidades de Fisioterapia/instrumentação , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
17.
BMC Endocr Disord ; 20(1): 124, 2020 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-32795274

RESUMO

BACKGROUND: Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats. METHODS: Sprague Dawley rats (250 ± 5 g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities. RESULTS: The body weight in the Ob group was increased compared to that in the control group, (p < 0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p < 0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p < 0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities. CONCLUSION: Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints.


Assuntos
Endotélio Vascular/diagnóstico por imagem , Coração/diagnóstico por imagem , Fígado/diagnóstico por imagem , Sistema Musculoesquelético/diagnóstico por imagem , Obesidade/diagnóstico , Anatomia Transversal , Animais , Endotélio Vascular/patologia , Endotélio Vascular/fisiopatologia , Coração/fisiopatologia , Molécula 1 de Adesão Intercelular/metabolismo , Fígado/fisiopatologia , Masculino , Doenças Musculoesqueléticas/diagnóstico , Doenças Musculoesqueléticas/etiologia , Doenças Musculoesqueléticas/patologia , Doenças Musculoesqueléticas/fisiopatologia , Sistema Musculoesquelético/patologia , Sistema Musculoesquelético/fisiopatologia , Miocárdio/patologia , Obesidade/complicações , Obesidade/fisiopatologia , Ratos , Ratos Sprague-Dawley , Ultrassonografia , Doenças Vasculares/diagnóstico , Doenças Vasculares/etiologia , Doenças Vasculares/patologia , Doenças Vasculares/fisiopatologia , Disfunção Ventricular Esquerda/diagnóstico , Disfunção Ventricular Esquerda/etiologia , Disfunção Ventricular Esquerda/patologia , Disfunção Ventricular Esquerda/fisiopatologia
18.
J Bone Joint Surg Am ; 102(14): 1197-1204, 2020 07 15.
Artigo em Inglês | MEDLINE | ID: mdl-32675661

RESUMO

Coronavirus disease 2019 (COVID-19) is an emerging pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the majority of patients who become infected with SARS-CoV-2 are asymptomatic or have mild symptoms, some patients develop severe symptoms that can permanently detract from their quality of life. SARS-CoV-2 is closely related to SARS-CoV-1, which causes severe acute respiratory syndrome (SARS). Both viruses infect the respiratory system, and there are direct and indirect effects of this infection on multiple organ systems, including the musculoskeletal system. Epidemiological data from the SARS pandemic of 2002 to 2004 identified myalgias, muscle dysfunction, osteoporosis, and osteonecrosis as common sequelae in patients with moderate and severe forms of this disease. Early studies have indicated that there is also considerable musculoskeletal dysfunction in some patients with COVID-19, although long-term follow-up studies have not yet been conducted. The purpose of this article was to summarize the known musculoskeletal pathologies in patients with SARS or COVID-19 and to combine this with computational modeling and biochemical signaling studies to predict musculoskeletal cellular targets and long-term consequences of the SARS-CoV-2 infection.


Assuntos
Infecções por Coronavirus/complicações , Sistema Musculoesquelético/fisiopatologia , Pneumonia Viral/complicações , Enzima de Conversão de Angiotensina 2 , Betacoronavirus , Osso e Ossos/fisiopatologia , COVID-19 , Simulação por Computador , Humanos , Articulações/fisiopatologia , Debilidade Muscular/virologia , Músculo Esquelético/fisiopatologia , Mialgia/virologia , Pandemias , Peptidil Dipeptidase A/genética , SARS-CoV-2 , Serina Endopeptidases/genética
19.
J Sports Med Phys Fitness ; 60(6): 889-894, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32487983

RESUMO

BACKGROUND: CrossFit® is usually composed of high intensity workout routines and is executed quickly, repetitively and with limited rest time. Previous studies have identified a high prevalence of injuries in CrossFit®. This study aimed to determine the prevalence of CrossFit-related musculoskeletal injuries and to identify potential associated factors. METHODS: A cross-sectional study was conducted with 413 CrossFitters. Participants completed a questionnaire containing personal data, training characteristics and injury history in the last 12 months. Data were analyzed by descriptive statistics and logistic regression models. RESULTS: The prevalence of CrossFit-related musculoskeletal injuries was 24.0%; and the injury rate was of 0.80 injuries per 1,000 hours of exposure. The regions of the body most affected were the lumbar spine (33.3%), shoulders (31.3%) and knees (14.1%). The majority of CrossFitters participated in competitions (74.6%), had more than 12 months of experience in CrossFit® (62.7%), and trained up to 90 minutes a day (82.3%) for more than 4 days a week (76.8%). The variables that showed a significant association with CrossFit®-related musculoskeletal injuries were weekly training frequency (OR=2.25; 95% CI: 1.13-4.48) and regular physiotherapeutic care (OR=1.85; 95% CI: 1.11-3.07). CONCLUSIONS: The prevalence of musculoskeletal injury was 24.0%, and the most affected regions of the body were the lumbar spine, shoulders and knees. Training more than four days a week and do not receive regular physiotherapeutic care were associated with CrossFit-related musculoskeletal injuries.


Assuntos
Traumatismos em Atletas/epidemiologia , Sistema Musculoesquelético/lesões , Adulto , Traumatismos em Atletas/fisiopatologia , Brasil/epidemiologia , Estudos Transversais , Feminino , Humanos , Vértebras Lombares/fisiopatologia , Masculino , Sistema Musculoesquelético/fisiopatologia , Condicionamento Físico Humano/efeitos adversos , Condicionamento Físico Humano/métodos , Prevalência , Inquéritos e Questionários , Adulto Jovem
20.
Rev. medica electron ; 42(3): 1792-1803, mayo.-jun. 2020. tab, graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1127041

RESUMO

RESUMEN Introducción: las enfermedades musculoesqueléticas son las causas más frecuentes de incapacidad en el mundo, lo que afecta gravemente la capacidad de las personas para desarrollar sus actividades habituales. Objetivos: describir el comportamiento del proceso rehabilitador de pacientes con trastornos musculoesqueléticos. Materiales y Método: se realizó un estudio descriptivo en el Servicio de Rehabilitación del Hospital Militar de Matanzas, desde julio 2017 hasta diciembre de 2017. Se estudiaron las variables: trastorno musculoesquelético diagnosticado, duración de la crisis dolorosa, presencia de vínculo laboral, incapacidad laboral asociada, inicio del tratamiento rehabilitador (precoz o tardío) y cantidad de sesiones de tratamiento fisiátrico Resultados: la sacrolumbalgia afectó al 22,4 % de los pacientes estudiados y la cervicalgia al 20,1 %. La duración media de estas afecciones fue de 14 días. El 64,7 % de los pacientes laboralmente activos presentó incapacidad temporal asociada. El 65 % de los pacientes se incorporó de forma tardía a la rehabilitación. Conclusiones: la sacrolumbalgia fue el diagnóstico más frecuente y con mayor incapacidad laboral asociada. La afección con la duración media más extensa fue la cervicalgia. La mayor parte de los pacientes se incorporó tardíamente al tratamiento fisiátrico (AU).


SUMMARY Introduction: The muscle skeletal illnesses are the most frequent causes of inability in the world, what affects the capacity of people gravely to develop their habitual activities. Objective: To describe the behavior of the rehabilitative process of patient with muscle skeletal dysfunctions. Materials and methods: A descriptive study was carried out in the Service of Rehabilitation of the Military Hospital of Matanzas, from July 2017 until December of 2017. The variables studied were: muscle skeletal dysfunctions diagnosed duration of the painful crisis, presence of labor bond, associate labor inability, beginning of the rehabilitative treatment (precocious or late) and quantity of sessions of physiotherapy treatment. Results: The sacrolumbalgia affected to 22,4% of the studied patients and the cervicalgia to 20,1%. The half duration of these affections was of 14 days. 64,7% of the patients laborly assets presented associated temporary inability. 65% of the patients incorporated from a late way to the rehabilitation. Conclusions: The sacrolumbalgia was the most frequent diagnosis and with more associate labor inability. The affection with the most extensive half duration was the cervicalgia. Most of the patients incorporated from a late way to the rehabilitation (AU).


Assuntos
Humanos , Fatores de Risco , Doenças Musculoesqueléticas/reabilitação , Sistema Musculoesquelético/fisiopatologia , Epidemiologia Descritiva , Estudos Prospectivos , Estudos Longitudinais , Modalidades de Fisioterapia , Doenças Musculoesqueléticas/diagnóstico , Doenças Musculoesqueléticas/epidemiologia , Licença Médica , Desempenho Profissional
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